Different aspects of each disease are reviewed including clinical issues treatments basic discoveries genetics and molecular biology and translation of basic research into biomarkers for early diagnosis. Most of the neurodegenerative diseases share several clinical pathologic and molecular aspects clinically these diseases are often characterized by an insidious onset during adulthood after which they progress at different rates ultimately leading to severe physical disability or death. Both clinical and basic aspects of each disease are treated including novel diagnostic criteria old and new treatments basic discoveries genetics epigenetics and molecular biology and translation of basic research into biomarkers for early diagnosis particularly to identify peripheral biomarkers. Ticozzi n silani v 2014 amyotrophic lateral sclerosis genotypes and phenotypes in neurodegenerative diseases clinical aspects molecular genetics and biomarkers springer verlag london ltd pp 179 192
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